Dear Friends and Family,

This will be my seventh PMC event. This year, I will be again riding with my kids, Becky and Tyler. In July, Becky will become an Instructor at Dana-Farber Cancer Institute, and she has been working in Ben Ebert’s laboratory studying leukemia and multiple myeloma. Tyler is working at an investment firm in New York called Praesidium. It is incredibly rewarding to ride the PMC with my family.

I have committed my life to helping people who have cancer. I hope that riding will help patients. This year, we have been studying how cancer begins using the zebrafish model. We use a technique called cellular barcoding that can be used to track clones of cancer cells as they expand. This should have a great impact on many cancer patients in defining the cell of origin of the cancer and following clones during treatment. The companies that I have started have also enrolled patients in clinical cancer trials including NK and T cells to kill tumors (Fate Therapeutics) and TGFb inhibition to help immune checkpoint blockade for cancer (Scholar Rock). I am also excited about the progress at Camp4, as we have our first drug in the clinic, and Triveni Bio is planning trials in the future. It is truly amazing to be a physician scientist at this time and I am proud that our bench research has made it to the bedside of patients. I hope that you will support me on my ride for the PMC and help us to continue to understand and fight cancer.

Every donation brings us closer by the mile.

Thank you,

Len